The Psychedelic Medicine
Knowledge Library
Evidence-based reference for practitioners, clinicians, and serious researchers. Browse free summaries or ask our AI for deeper analysis.
Browse by Category
Classic Psychedelics
Psilocybin, LSD, DMT, mescaline — mechanisms, research, and clinical applications
Plant Medicines
Ayahuasca, ibogaine, peyote — traditional use, pharmacology, and modern research
Dissociatives & Empathogens
Ketamine, MDMA, 5-MeO-DMT — therapeutic protocols and clinical evidence
Conditions & Indications
Depression, PTSD, addiction, anxiety — evidence summaries by condition
Clinical Protocols
Dosing, preparation, integration, screening — practitioner-grade reference
Hawaiian Medicine
Lomilomi, la'au lapa'au, Reiki — traditional healing within the Kumulipo tradition
Featured Entries
Ask AI a questionIbogaine
A naturally occurring psychoactive alkaloid from the Tabernanthe iboga plant. Studied extensively for its potential to interrupt opioid dependence and reset reward pathways.
Psilocybin
The primary psychoactive compound in psilocybin mushrooms. Phase 2 and 3 clinical trials show significant efficacy for treatment-resistant depression and end-of-life anxiety.
Ketamine & MDMA
Two distinct compounds increasingly used in combination for trauma processing. Ketamine provides rapid antidepressant effects; MDMA facilitates emotional processing and therapeutic alliance.
Ayahuasca
A traditional Amazonian brew combining DMT-containing plants with MAOIs. Emerging research supports its use for depression, addiction, and existential distress.
LSD (Lysergic Acid Diethylamide)
A potent synthetic psychedelic with a long duration of action. Early research from the 1950s–70s showed promise for alcoholism and anxiety; modern trials are revisiting these findings.
Hawaiian Healing Traditions
The Kumulipo creation tradition and its relationship to healing — lomilomi, la'au lapa'au, and the role of spiritual practitioners in psychedelic integration.
Biased Agonism at 5-HT2A Receptors
How downstream signaling differences at the 5-HT2A receptor — β-arrestin vs.Pro access required for full content.
Ibogaine Cardiac Safety Protocols
QTc interval monitoring, contraindications, pre-treatment cardiac workup, and intraoperative management for ibogaine-assisted therapy programs.Pro access required for full content.
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Educational Use Only. All content is for informational purposes and does not constitute medical advice. Consult a qualified physician before making any health decisions. Psychedelic substances carry risks and vary in legal status by jurisdiction.